Maria's investigation into her mother's disappearance leads her and Alex to the home of a mysterious boot maker named Travis. Meanwhile, on her journey of self-discovery, Isobel's night out leads her into the arms of someone unexpected. Finally, after making some major scientific strides, Liz is dealt a devastating blow.

Despite promising Liz that he'll take things easy with his new heart, Max sets out to find Cameron after learning that she's gone missing. Michael grows concerned about Maria after a surprising discovery about her family history leaves her vulnerable. Elsewhere, ready to move on, Alex goes on a date with Forrest, and Rosa makes a decision about her future.