Despite promising Liz that he'll take things easy with his new heart, Max sets out to find Cameron after learning that she's gone missing. Michael grows concerned about Maria after a surprising discovery about her family history leaves her vulnerable. Elsewhere, ready to move on, Alex goes on a date with Forrest, and Rosa makes a decision about her future.

After uncovering a cryptic message from the past, Alex, Isobel, Max, Michael and Maria set out in search of answers at the reservation where Alex's mother grew up. Meanwhile, Cameron encourages Liz to reach out to someone from her past after Auturo gets detained.