Noel treats nine-month-old cockapoo Betsy, whose owners Sophie and Dan are concerned about a dragging front paw caused by nerve damage, to see if there are surgical options. But when Betsy develops gangrene, she has to have her paw amputated, and in order to salvage the rest of her limb, Noel must replace her amputated foot with a skeletally-anchored implant called a PerFiTS (Percutaneous Fixation to the Skeleton).

A 10-year-old Dobermann is treated for an aggressive bone tumour in its leg. One option is a full limb amputation, but another could potentially save Rolo's leg by cutting out the affected part of the bone and replacing it with a unique implant of Noel's own invention - a scapula-humeral endoprosthesis. Five-year-old labrador Jeff is suffering from developmental elbow disease, which cannot be managed by medication alone. The day of his planned surgery for a full elbow replacement arrives, though bad news places the prospect of such treatment in jeopardy and ferret Astrid, who's broken her leg falling off a sofa doing a 'war dance'.