Tig Notaro, an LA-based radio host, returns to her hometown of Bay St. Lucille, Mississippi, to be at the bedside of her ailing mother, Caroline. Suffering from her own recent health problems, Tig attempts to reconnect with her brother, Remy, and stepfather, Bill, both of whom lack the emotional tools to deal with family trauma.

Bill's cat escapes and he blames Tig for letting her out. Tig's biological father, Mick, leads a search party. Assigned to survey the neighborhood, Tig unearths a secret from Caroline's past. Having found a local station where she can record her show remotely, Tig connects with Kate, the off-beat radio station manager.