As crews begin to book on for the start of the day shift, an emergency call is received for a patient who has made an attempt to end their life. Crewmates Emily and Gayle are immediately dispatched to assist another crew. As they make the ten-minute journey to provide back-up, the patient is confirmed dead, but Emily and Gayle decide to remain at the scene and help provide some much-needed support to the grieving family.

In Pallion, crewmates James and Jamie are dispatched to a 71-year-old female with upper back pain. The crew are in awe of the patient as they learn how she has dedicated her life to caring for others and volunteering for charity.

Nearly two hours into the shift, control are answering a new call every 42 seconds. Emily and Gayle are sent to treat a 99-year-old female who is struggling with low oxygen levels. Soon to celebrate her 100th birthday, the patient has a wealth of stories to share from her glittering past, including working for 20th Century Fox and being called up to work for the forces during the Second World War.

In control, an emergency call is received for a patient who is not breathing. Things take a turn for the worst when crews arrive to find there is a second patient, a child, also in cardiac arrest and in need of urgent help.

On the afternoon shift, category one calls come flooding in, with over 50 patients waiting for an ambulance across the region. James and Jamie respond to an emergency call for a 75-year-old female who is believed to be having a stroke. At the scene, the patient's husband explains that having tried multiple non-emergency pathways to try to get help, they were left with no choice but to call 999.

Emily and Gayle are sent to help an 81-year-old diabetic patient who has fallen off his mobility scooter. There is cause for concern after the crew take a look in the patient's fridge and find an abundance of sugary drinks. Emily puts all jokes to one side as she speaks frankly to the patient about the impact his lifestyle could have on his long-term health.