A Young man vows to walk again after a tragic car accident leaves him in a wheelchair; a couple suffers through 15 years of infertility; a deaf veteran longs to hear her children's voices; a middle-aged housewife aspires to be a bodybuilder.

Host Cat Deely welcomes people who make a commitment to complete a life changing, yearlong goal whose results the audience will see instantly. An adopted man searching for his biological family, a woman yearning to lose 60 pounds, a couple who has struggled with fertility issues hoping to have a baby, a formerly obese young woman who wants to have the excess skin from her weight loss removed, and a lifelong stutterer who wants to overcome her affliction and perform stand-up comedy while her ailing mother can still watch her.