Will and Faith fight to clear an innocent woman's name while uncovering a deadly drug ring. Meanwhile, Angie spirals after a traumatic event, and Ormewood grapples with his diagnosis, unsure of how much to share with those closest to him.

Unleashed by a domestic terrorist group, a mysterious biological attack runs rampant in Atlanta. As Will and his team race to contain the threat and save countless lives, he's forced to confront the complex dynamics of his own family.