When disillusioned A-list Hollywood actress Mira Harberg arrives in Paris to immerse herself in the coveted role of iconic villainous Irma Vep in a remake of Feuillade's The Vampires, an encounter with her former lover Laurie reignites dormant passions. Meanwhile, the project's acclaimed director Rene Vidal struggles as production woes threaten to derail his vision.

A surprising heart-to-heart with her ill-mannered co-star Gottfried causes Mira to revisit her past, while René is haunted by his relationship with his ex-wife – who played the role of Irma Vep in his 1996 film. Later, a breakthrough with Edmond leads to another on-set catastrophe.