Davina McCall and Nicky Campbell follows the stories of two women looking for siblings given up for adoption, but for very different reasons. Jeanette Woodyatt wants to find the brother she has never met and who was turned away from the family by her grandmother, while Karen Turnbull yearns to let her twin siblings know that their mother gave them up for adoption so they would have a better life.

Davina McCall and Nicky Campbell present the stories of two men, both of them born in Ireland to unmarried mothers at a time when having children outside of marriage was seen as sinful and the Catholic Church went to great lengths to cover it up. When Arthur Fitzharris's adoptive parents died he decided to find out about his birth family, and was dismayed to discover that his birth certificate falsely recorded early foster parents as though they were his biological parents. Bernard McGrath discovered his adoptive parents were falsely named as his biological parents on his birth certificate and no other records seemed available to him.