Davina McCall and Nicky Campbell help more people to reunite with long-lost relatives. Alice Jones was brought up by her father, but on a visit to her mother more than 50 years ago she met her younger brother called Sam and has always hoped that one day she would see him again. Mark Ratcliffe grew up in Lancashire and at the age of 12 his parents told him he was adopted and the revelation devastated him. Ever since, he cannot shake the question of how a mother could give up her child and is now looking for answers.

In a first for the programme, Davina McCall and Nicky Campbell present an appeal for information on behalf of two families whose loved ones have been reported missing to the police. They look at the cases of Matthew Bone, who disappeared in March 2018, and Simon Greaves, who went missing five years ago. They also follow the story of Beryl Everall, who last saw her mother more than 60 years ago when she mysteriously disappeared from her life. All contact with her mother's side of the family was lost, and she was never spoken of again.