Hosted by Jane Pauley. In our cover story, David Pogue looks at what happens following the announcement of effective coronavirus vaccines. Plus: Seth Doane talks with Charlie Mackesy, the British artist behind "The Boy, the Mole, the Fox and the Horse"; Rita Braver interviews Meryl Streep, Candice Bergen and Dianne Wiest, co-stars of "Let Them All Talk"; John Blackstone meets a young portrait photographer documenting the stories of Toronto's homeless; Tracy Smith sits down with George Clooney, star and director of "The Midnight Sky"; Faith Salie looks at those wily urban survivalists, raccoons; Mo Rocca talks with peace educator Colman McCarthy; and Kelefa Sanneh meets three scientists who spent months in isolation this COVID season in a unique locale: a New England island, home to endangered seabirds. 

Guest host: Lee Cowan. In our cover story, Jim Axelrod talks with "Humans of New York" photographer Brandon Stanton about his book of international portraits. Plus: Erin Moriarty reports on an Indiana town where dozens of children have fallen ill with cancer; Mark Phillips looks at the controversy over the hit Netflix series "The Crown"; Tracy Smith goes behind the scenes of Chadwick Boseman's last film, "Ma Rainey's Black Bottom"; Kelefa Sanneh talks with singer and guitar virtuoso José Feliciano ("Feliz Navidad"); Faith Salie investigates the decades-long appeal of teenage sleuth Nancy Drew; Techno Claus (a.k.a. David Pogue) offers recommendations for tech gifts for the holidays; and we look at the history of Hanukkah, the "Festival of Lights."