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Eliza is hired to solve a case of blackmail in the shady world of Victorian medicine, and finds herself with a new rival - Patrick Nash, the owner of a large private detective agency who wants to hire her or crush her agency.
Eliza is forced into hiding when she is the prime suspect in a series of break-ins at city mortuaries. While Duke tries to find other suspects, Eliza turns to Moses and her other associates for help.
A famous mystery writer is at the centre of Eliza's investigation when a series of murders copy scenes in his books. Meanwhile, the Duke is also juggling problems at work with a new superintendent and a troubled young detective.
In Season 2, London's first-ever female detective, Eliza Scarlet continues to grow her private detective firm with the somewhat reluctant help of her friend (or more-than-friend?) police detective William "The Duke" Wellington.