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As Leonardo's achievements are recognized and his reputation grows, a risky decision could destroy everything he worked for.
In Milan, in 1506, Leonardo da Vinci was arrested on charges of having poisoned Catherine of Cremona.
Leonardo ventures to Milan, determined to claim an offer of patronage from the Duke Regent, Ludovico Sforza. When the reality of the situation turns out to be less appealing, a newfound relationship helps liberate Leonardo's imagination.