Leonardo ventures to Milan, determined to claim an offer of patronage from the Duke Regent, Ludovico Sforza. When the reality of the situation turns out to be less appealing, a newfound relationship helps liberate Leonardo's imagination.

After the death of Ludovico's wife, Leonardo is given a new art commission, but struggles with inner turmoil. After reflecting on wise words from Father Luca Pacioli, Leonardo seeks assistance from friends and presses on with the work, despite tensions in the city. Putting his creativity to the test and experimenting with a new technique, he must deal with the consequences of his actions and results.