In this episode, Paul meets 13-year-old Mackenzie, who was born with microtia, a condition that meant his left ear was underdeveloped. He also meets brother and sister Emily and Luke, who were both born with cystic fibrosis, and gutsy nine-year-old Lara who has a blood disease that has affected her since she was a baby.

In the third episode of series, Paul meets 11-year-old patient Fazeel, who suffers from a rare condition known as EB, which effects just 5000 people in the UK and currently has no cure. Fazeel's condition means he has delicate, painful skin and also needs regular eye checks to look for damage or blistering inside the eye.