In the second episode Paul meets 13-year-old Lola who has been in hospital for four weeks after being diagnosed with Juvenile Dermatomyositis which has caused inflammation of her muscles and skin. When Paul meets Lola her muscles are so weak and she can't walk, but her mum explains that just six weeks earlier she had been fine. The condition affects one in a million people and Lola needs physiotherapy to help her. Paul is there when Lola tried to take some steps for the first time in two months.

Also in the programme, Paul meets ten-year-old Oscar who has Tourette's. Oscar mostly has motor ticks, which means he sniffs and coughs. He explains that it's a human glitch which causes him to have involuntary movements. But he tells Paul that after developing Tourette's he became too anxious to leave the house.

In episode four Paul meets five-year-old Cora who has Cerebral Palsy. Thirty thousand children in the UK have the condition which affects coordination and muscle control. Cora's mum Poonam explains that Cora has a stiffness in the right side of her body which is causing her to limp and struggle with normal movements.

Cora is at GOSH to take part in ground breaking research which uses Botox to relax the over-active muscles. Paul goes with Cora to the sensory room to try to distract and relax her whilst she has the injections. And the programme follows Cora after the injections to see if they have worked.

Also in episode four, Paul reveals that he's developed a soft-spot for babies. GOSH treats 6000 babies every year and Paul goes to meet three-month-old Oliver who was born with a cleft lip. Paul is with Oliver as he enters theatre to have his cleft lip repaired.