After a number of women are murdered in East Cleveland, residents fear there may be a serial killer on the loose. When a grandmother is strangled and left to die on a vacant lot Detectives Bob Ford and Tom Armelli need to find out if her killing is related to the others. In Dallas, a young father is shot to death in his girlfriend's arms, in the back of his car. Detective Leo Gonzalez must find the killer before more bloodshed occurs.

A New Orleans homicide detective hopes that surveillance footage can help him solve the case of a young father who was abducted and shot in the street.