In Dallas, Detectives Scott Sayers and Ken Penrod are investigating a home invasion that left a young man dead. Is their suspect just a young suburban mom, or a criminal mastermind? And in Cincinnati, a brutal stabbing ends the life of a hard-working grandfather. After interviewing a series of family members, Det. Jenny Luke finds out that her suspect may be closer than she initially thought.

In Memphis Sgt. Eric Freeman and the homicide team investigate the high-profile murder of a University of Memphis college football player found shot in his car near the university campus. Investigators must determine if the victim's long-standing feud with a fellow student resulted in a deadly vendetta.