In Australia, Mike Rowe teams up with local business "Snakes Away" to capture a poisonous Eastern brown snake without getting bitten, then joins a posse of local "toadbusters" in their war against the cane toad, a non-indigenous species destroying the local ecosystem. 

Mike and his crew travel deep into the Australian Outback to strike it rich with a group of opal miners. And then, with this already a dirty adventure with dangerous work and extreme temperatures, production is almost brought to a halt by a fly infestation.