Peter volunteers as photographer for an old Pullitzer winner discarded by Jonah. The discover the underworld's recently release former kingpin Sable Manfredi is auctioning genetic technology to create monsters at will. As Spiderman, he tries to keep it out of the bid-winner's hands, but soon finds that also means taking on sore losers.

In order to become the new Big Man, Hammerhead betrays Tombstone, Doctor Octopus and Silvermane. Now, an all out gang war has erupted in New York City, and it's up to Spider-Man to stop it.