In order to become the new Big Man, Hammerhead betrays Tombstone, Doctor Octopus and Silvermane. Now, an all out gang war has erupted in New York City, and it's up to Spider-Man to stop it.

Editor Jonah roots against Spiderman when he tests if a new Oscorp top-security penitentiary design is escape-proof. Not only does he succeed in tricking the guards, Green Goblin-orchestrated sabotage releases the freak-thugs, so they can chase Spidey while he's trapped inside.