Just before he's to be hung, stage robber Shadler busts out of jail, by slugging his last rites priest and donning the robes as a disguise. While burglarizing an uninhabited farm, the escapee helps Deputy U.S. Marshal Newly elude hostile lawmen quarantining a nearby outpost struck by a mysterious plague. Newly believes his pursuers are actually a ring of vultures waiting to loot the dying settlement. When Newly heads back to the besieged town, the fake padre insists on riding with him to minister to the dying citizens. Why is the hardened Shadler risking his health and freedom to throw in with law enforcement?

Matt Dillon rides wearily into Dodge City after thirty-six hours in the saddle. At the office he can't get to sleep because Festus is so exuberant about everything. In the course of the day Matt fights with a prisoner and is stabbed with a fork. Kitty will not talk to him because duty caused him to miss a picnic. There is a brawl in the Longbranch Saloon. A young boy locks a crotchety old woman in a safe that has no available combination. Finally, Matt takes things into his own hands.