Manfred Bernardo, a powerful psychic on the run, decides to hide out in the small, sleepy town of Midnight, Texas. But when he's haunted by the ghost of a recently murdered Midnighter, Manfred discovers this sleepy community is a mysterious safe haven for outsiders with secrets - both supernatural and human - including Lemuel, an energy-leeching vampire; Olivia, a beautiful assassin; Fiji, a witch with a cranky cat; Creek, a spunky writer with big dreams; Bobo, a pawnshop owner with a hidden past; the Rev, who has an obsession for animals; and Joe, an angelic tattoo artist. In addition to the colorful residents, Manfred learns the town itself sits on a veil between the living and dead. He pledges to join the Midnighters in the fight to protect their home from suspicious cops and other outside forces.

A deadly nest of vampires arrives in Midnight and it turns out they're old friends of Lem's eager to reunite. Manfred suspects there's more to their arrival and joins forces with Olivia to uncover the real story while Creek prepares for the worst. Elsewhere, Fiji and Bobo hatch a plan of their own in case the vampires are up to no good. Meanwhile, Joe confides his suspicions about the veil to hell opening in Midnight to the Rev.