When a pharmacist is found shot to death in his Wisconsin farmhouse, investigators embark on a 15 year hunt for his elusive killer.

Two murders in Toronto ignite an investigation that spans four decades; breakthroughs in investigative genetic genealogy help crack the case.

An investigation into the poisoning of Wisconsin mother-of-two Julie Jensen takes a surprising turn when detectives learn that she wrote a letter days before her death pointing to a possible suspect.

After an apparent home invasion in Minnesota leaves Heidi Firkus dead and her husband, Nick, hospitalized, detectives learn the young couple was facing financial troubles.

When Leslie Neulander dies after what seems to be an accidental fall in the shower, her book club friends join forces to seek justice on her behalf. Andrea Canning reflects on some of the most determined women she's ever met.