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The ER is quarantined, which prevents Kayo from going to her sister's wedding, detains Doyle's accountant and jeopardizes a sick runaway.
Kayo fights to perform heart surgery on a patient (Miriam Colon) who's not insured. Her son challenges Dr Doyle to a fistfight after the physician insults the lady.
A department-store explosion creates a major disaster as patients are rushed to Manhattan General during the midst of the Christmas season.