A trip to Napa concludes with tensions at a high. Back in the OC, Vicki and Brooks consider some unconventional cancer treatments, Meghan puts the final touches on her first OC charity event while Heather faces the harsh reality of going over budget on her dream home. Meanwhile, Shannon receives some shocking news and unresolved issues between her and Meghan become the topic of the ladies' scrutiny at Meghan's JDRF charity event.

The passing of Vicki's mother sends shock waves through the group, causing everyone to reflect on family; Tamra celebrates the birth of her granddaughter; Shannon continues to repair her marriage; Meghan tries to create a lasting memory for Hayley.