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Sharko integrates Lucie into the crime squad. They investigate the medical files kept by Clinic Moreau and discover the images of the film entitled Syndrome E.
In Casablanca, a young boy named Walid is kidnapped in a mysterious van. At the same time, in Paris, the lieutenant of the BAC, Lucie Henebelle, begins to cry tears of blood and shoots his partner.
Lucie is more and more disturbed by this syndrome, which seems to be able to tip her at any time into ultra-violent crises. Sharko sees her distress, and their mutual attraction grows.