A day full of emotions awaits psychiatrist Henri Lacombe and his wife Anne Beaulieu, a psychologist by profession. Anne still insists with Henri to go out for supper. In the evening, Anne never shows up at the restaurant. Unusual behavior on his part. Henri looks for her, but his wife cannot be found. Powerless, he alerts the authorities. His nightmare becomes real when his file is referred to Simone Vallier, a major crimes investigator: his wife is indeed missing.

Simone and Danno continue their investigation and the story of Patrick Lemire, Henri's patient who took his own life, resurfaces. Richard and Sophie show great solidarity with the family of their great friend. Marine takes advantage of their presence to confess to her father a secret that eats away at her. Back home, Marine confronts her roommate Alice and especially her journalist sister, about the consequences of the biased interview she conducted with her mother.