After Rose returns home from a tropical resort, a small blemish on her face begins to grow into something out of a nightmare. Discovering that a bite from a spider has infected Rose, her partner, Ben, must race to save her from a horrifying physical and psychological breakdown.

After her neighbor is brutally murdered, a woman installs a new security system in her home and adopts a Doberman for protection. But when her dog is rushed to the vet, she's left alone to outwit the murderer, who is now targeting her.