Crime experts explore the motives and modus operandi of female killers. While males are often driven by anger, impulse and destruction, women usually have more complex, long-term reasons to kill.

Rita and her microbiologist husband, Yakov Gluzman, flee Soviet Ukraine for America; when Yakov wants to split, Rita plots his demise; Cheryl Lynn Lucero is quite fickle until she meets her soul mate; he then rejects her and she seeks deadly revenge.