The Millennium Group investigates the suicides of identical twin girls born seven years apart. They soon find out that a man and his bizarre family of cloned daughters are preparing for the apocalyptic disaster of May 5th, 2000, when a celestial alignment of the planets take place.

Frank Black's private and professional lives clash when his sister-in-law is abducted by a convicted sex offender at her child's baptism. Although Bletcher orders him to stay out of the investigation because he is too close to the case, he cannot help but become involved. However, even his extraordinary abilities might not be enough to find his brother's wife.