Frank assists in the hunt for a man who is apparently infected with a deadly, highly contagious virus. Frank and Peter then begin to wonder if a member of the Human Genome Project could have tampered with the DNA that controls human violence.

When a Manhattan construction site unearths a body of a Native American man, Frank is called in because it seems he was slaughtered in an apocalyptic ancient ritual. At the site Frank learns more about the Indian culture and he begins to unearth many strange prophecies involving the resurrection of Indian men and the destruction of the white man from the west. Frank also begins to learn a little more about his visions.