When Frank and Peter help track down Landon Brice, an ordinary teenager who recently went missing, they believe that the boy was abducted. But the investigation brings Frank to believe that Lucy Butler (the prime suspect in the murder of his friend Bob Bletcher) is behind an entire series of abductions so he sets out on a mission to avenge Bob's death.

Frank and Peter are quarantined after they come in contact with an unknown pathogen which has caused several people to die. Meanwhile Jordan experiences a terrifying nightmare and Lara Means disappears under mysterious circumstances.