In the aftermath of the previous battle, Kamina, Simon, and Yoko proceed to forage for provisions. However, a chance encounter with a formidable Beastman, Viral, and his powerful Gunman forces the Gurren and the Lagann to combine to form a new Gunman.

Team Gurren's journey brings them to an underground village, where society mandates a humbling existence and the worship of Gunmen as divine beings. Team Gurren is joined by Rossiu and two children, Gimmy and Darry.