Guided by Simon and Nia's feelings for each other, Team Dai-Gurren break through dimensions in search for the Anti-Spirals' homeworld. But after falling into the enemy's trap, they end up losing some of their most precious members, due to its vicious offensive.

After merging with Lorgenome's ship and transforming into the gigantic Super Galaxy Gurren-Lagann, Simon and his friends successfully fight back against the enemy. However, the enemy traps them in a world of dreams and desires. Just when all hope seems lost, an ally from the past reappears.