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Many centuries ago, one alien ship crashed on earth. The surviving aliens were defeated by a local Indian tribe. The modern day aliens attempt to acquire the ship to assist in their subjugation of the planet.
A noted scientist and old friend of Suzanne's, Dr. Erik Von Deer, is being brain-washed (through signals subliminally implanted in the music of his favorite artist) into secretly working on a serum that will give the aliens immunity to Earth's bacteria. Suzanne arrives for a weekend visit while Von Deer is on the verge of the serum's completion.
The Blackwood Project investigates individuals who claim to have had "close encounters". The team stumbles onto an alien plot involving implanting something into victims' bodies for the study of the human immune system, setting them free and collecting them later to learn the results. Harrison ends up dating one of the victims, Karen McKinney.