Paramedics respond to everyday people having their worst day. Daniel rushes to a woman having a life-threatening allergic reaction from a takeaway. Sam and Chris struggle to help a partygoer after an accident in the busy nightclub district.

Olivia and Sally become medical detectives as they examine a woman having potential stroke. Paramedic Bill races to a man having seizures. The patient is going downhill fast and could lash out at the very people trying to save him.