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Stephens musters the courage to ask Watson to help him when his camgirl suddenly collapses during a video call; the team must act quickly to locate her before it's too late; Watson grapples with guilt over Sherlock's death.
Watson takes a major ethical risk when he decides to treat a sickle cell patient with an unorthodox surgery; Ingrid struggles to get her sister admitted to her spinal project.
While Watson and the team help a woman whose memory resets every three minutes, Watson struggles with auditory hallucinations and questions whether someone is behind his current decline; Moriarty plots his next move.
A year after the death of his friend and partner Sherlock Holmes, Dr. John Watson resumes his medical career as the head of a clinic dedicated to the treatment of rare diseases. However, he soon finds that his old life is not done with him.