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When part of the team falls ill after becoming targets of a sinister plot, it becomes an all-hands-on-deck situation to save them before it's too late; Watson announces a new ambitious project that he has been working on.
Watson confronts a traumatic event from his Army days that still weighs heavily on him after his friend's wife reaches out begging for help when her husband is seemingly having a psychotic break; Shinwell is asked for one last favor by Moriarty.
Watson and the team are faced with an impossible choice when two lives hang in the balance, but they only have one vial of antidote available; Shinwell races to help the team; Watson goes head-to-head with Moriarty.
A year after the death of his friend and partner Sherlock Holmes, Dr. John Watson resumes his medical career as the head of a clinic dedicated to the treatment of rare diseases. However, he soon finds that his old life is not done with him.