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Watson and the team are faced with an impossible choice when two lives hang in the balance, but they only have one vial of antidote available; Shinwell races to help the team; Watson goes head-to-head with Moriarty.
When part of the team falls ill after becoming targets of a sinister plot, it becomes an all-hands-on-deck situation to save them before it's too late; Watson announces a new ambitious project that he has been working on.
A year after the death of his friend and partner Sherlock Holmes, Dr. John Watson resumes his medical career as the head of a clinic dedicated to the treatment of rare diseases. However, he soon finds that his old life is not done with him.