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Watson's father, Hamish, visits UHOP to introduce Watson and the fellows to his protégé, Annabelle, a saxophone prodigy with musically induced blackouts.
Watson and the fellows race against time to save the life of Xavier, a 21-year-old athlete with a fast-growing, seemingly incurable cancer; Mycroft Holmes lets Watson know his team's work at UHOP may no longer have funding available.
Watson and the fellows are taken hostage by a man with a bomb strapped to his chest who is desperate to find a cure for his 9-year-old daughter's illness.
With his eyes fixed on the future, Watson faces an unexpected twist when Sherlock Holmes, who was presumed dead, resurfaces, forcing him to confront a buried secret from his past—one that lies hidden within his own body.