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While visiting another hospital, Watson becomes convinced that a man is suffering from locked-in syndrome and has been mistaken for a coma patient for over a decade; Sherlock is back in town and is staying with Watson.
Watson and the team jump into action when four people become infected with a flesh-eating bacterium; Shinwell searches for meaning as a nursing student; Adam's wedding to Lauren risks being halted.
Watson and the fellows race against time to save the life of Xavier, a 21-year-old athlete with a fast-growing, seemingly incurable cancer; Mycroft Holmes lets Watson know his team's work at UHOP may no longer have funding available.
With his eyes fixed on the future, Watson faces an unexpected twist when Sherlock Holmes, who was presumed dead, resurfaces, forcing him to confront a buried secret from his past—one that lies hidden within his own body.