In the border town of Juarez, a trafficker explains how heroin is transported to the US as Mexican Federal police undertake an operation to bust a dealer. In Columbus, Special Agent James executes a significant drug bust and starts tracking the local heroin supply back to its cartel sources when a key suspect disappears. In Atlanta, John hits the street to feed his habit before an impending court date but feels guilty for manipulating his family.

In Columbus, Sergeant Nate Smith helps recovering addicts get treatment while zeroing in on a dealer who's mixing heroin with lethal Fentanyl. In Mexico, Don Miguel finds himself trapped in the drug trade, while Mario, a young activist, looks for his missing brother. Back in Atlanta, Skyler signs himself up for long-term treatment but struggles to follow through.