Davina McCall, Maya Jama, Adam Hills and Alan Carr host a spectacular, star-studded evening of entertainment to raise funds for vital cancer research, with Joe Lycett cajoling the audience all night via his high-tech hub with help from his nationwide band of celebrity reporters. Over the course of the night, the initiative is supported by stars including Olivia Colman, Usain Bolt, Jack Black, Tom Jones, Kris Jenner, Kim Kardashian, Sue Perkins, Rosie Jones, Mo Gilligan, James Blunt, Kate Beckinsale, Steve Coogan, Jeremy Clarkson, Josh Widdicombe, Jamie Oliver and Natalie Imbruglia appear. Friends and family members compete in fiendishly silly challenges, and famous faces throw themselves into ridiculous stunts, all to illustrate the impressive science behind SU2C's goal of ending cancer.

A sketch of the hit series, set in 1990s Northern Ireland. Plus, James Blunt gives his song You're Beautiful an eyebrow-raising reboot, and Usain Bolt takes on more challenges. Harry Styles gives viewers a peek behind the celebrity curtain, and there's the first glimpse of tonight's Celebrity Gogglebox.