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The Fantastic Four are brought to the Negative Zone where they come face to face with Annihilus. As if that wasn't bad enough, Dr. Doom arrives stealing Annihilus' power source and threatening Earth.
Doctor Doom hijacks one of Reed's experiments aimed at restoring Ben Grimm to human form and causes the FF to swap powers with one another.
The Mole Man attacks the Baxter Building in hopes of luring the FF to his underground lair.