The Titans try for a season sweep of the Colts. Tennessee topped Indianapolis 25-16 in Week 3 for its third victory in the last four meetings. The Titans' Derrick Henry has rushed for 977 yards and six touchdowns in 11 games against the Colts.

The Titans host the Saints. Tennessee has won three straight at home, defeating Indianapolis, Buffalo and Kansas City. The Titans' Derrick Henry rushed for 342 yards and three touchdowns in those games. New Orleans has won three in a row on the road.