In the dead of night, a menacing giant cat is stalking across Manhattan & stealing valuables - furs, jewelry, cash - and bringing it back to a tiny apartment. The cat is the product of a demented sorcerer named Pardo, who is planning a vile scheme - to rob Manhattan's wealthiest citizens and then sap the souls out of their bodies. At a movie theater the following night, Peter attends a premiere of a strange film called 'My...Pet' with his girlfriend, Polly. When the film starts, the giant cat appears, and begins gassing the audience with a noxious gas that puts them into a trance. Peter is the only one who is immune to it, and he immediately changes into Spider-Man to put a stop to it. As Pardo's men drive around the theater robbing patrons, Spidey puts a stop to them, then bursts into the camera room & catches Pardo in the act. The psychotic sorcerer jumps into a chair & flies into the huge eye on the screen, and Spidey follows. Spidey finds himself in a huge water tank, with a giant cat peering down at him. He ducks out of sight, as the cat causes tremendous panic amongst the theater-goers. Spidey emerges from the tank & leads the giant cat across Manhattan, towards a confrontation on the Brooklyn Bridge, where Spidey has a plan to put an end to Pardo's reign of terror.

Peter Parker travels with Penny Jones in the Daily Bugle plane to the Antarctic to photograph a downed space capsule. After a crash landing on an island, Spider-Man must rescue Penny from a primitive tribe bent on human sacrifice.