Lester Holt reports the day's major international and domestic news stories each weeknight. The broadcasts also feature human-interest segments called Making a Difference, which spotlight ordinary Americans who positively affect the lives of those around them.

Lester Holt reports the day's major international and domestic news stories each weeknight. The broadcasts also feature human-interest segments called Making a Difference, which spotlight ordinary Americans who positively affect the lives of those around them.