An urgent manhunt is underway in Birmingham, Alabama after gunman killed 4 people; Americans warned to leave Lebanon as Israel and Hezbollah ramp up deadly attacks on each other; A new NBC News poll shows Vice President Harris ahead of Trump; and more on tonight's broadcast.

Tropical Storm Helene expected to rapidly intensify into a major hurricane; Biden, in final U.N. speech, says world is at an "inflection point"; Israel bombards southern Lebanon and Beirut for a second day; and more on tonight's broadcast.