Bruce Banner goes to Washington, D.C., and visits his cousin Jennifer Walters. The two of them are attacked by robots sent by Dr. Doom. The robots kidnap an injured Jennifer and Doom threatens to kill her if the Hulk does not obey him. The Hulk turns back into Banner when Jennifer's condition worsens. Banner gives her a blood transfusion before Doom uses technology to transform him back into the Hulk. On Doom's instruction, the Hulk goes on a rampage against the U.S. military. Meanwhile, Banners blood turns Jennifer into the She-Hulk. She attacks Doom and frees the Hulk before he destroys the capital. Hulk and She-Hulk work together to defeat Dr. Doom. Meanwhile, the Leader dismisses Gargoyle who steals some of his data before he departs.

Bruce Banner wakes up in South Dakota and General Ross goes after him with his Hulkbusters. Meanwhile, a gamma virus breaks out in Detroit and Betty travels there to assist Donald Blake. Blake transforms into Thor and heads off to get the Hulk. Thor takes Hulk to Detroit, but the two fight, which drives the Hulk away. Banner returns and realizes there is a Gamma virus outbreak. He meets Betty at the hospital and works to fix the virus. After an accident, Betty is exposed to the virus. The Gargoyle realizes that the Hulk is in Detroit and so sends the Abomination to kidnap him. The Gargoyle reveals that he accidentally created the virus in an attempt to cure himself. Banner works with the Gargoyle to create a cure for the virus. He manages to synthesize a serum, but the Abomination attacks and the Gargoyle flees with the serum. Thor arrives to rescue the Hulk and return Banner to the hospital. Blake and Banner work on a cure, but it won't be ready in time to save Betty. Fortunately, the Gargoyle appears and gives a serum to Banner to cure her.